/* Arial-based typography — no external font dependencies */

/* ─── DARK THEME (default) ─── */
:root {
  --bg:          #0e1117;
  --surface:     #161b27;
  --surface2:    #1e2535;
  --border:      rgba(255,255,255,0.07);
  --border2:     rgba(255,255,255,0.13);
  --accent:      #1e90ff;
  --accent-h:    #4dabff;
  --green:       #2ecc71;
  --red:         #ef5350;
  --text:        #e6edf3;
  --muted:       #7d8a99;
  --banner-bg:   rgba(14,17,23,0.97);
  --nav-bg:      #161b27;
  --card-shadow: 0 2px 12px rgba(0,0,0,0.4);
  --banner-h:    130px;
  --nav-h:       44px;
}

/* ─── LIGHT THEME ─── */
[data-theme="light"] {
  --bg:          #e8eef7;       /* lighter blue-gray page background */
  --surface:     #f5f8fd;       /* card faces: near-white, clearly lighter than bg */
  --surface2:    #d8e2f0;       /* inputs, table headers */
  --border:      rgba(0,0,0,0.18);
  --border2:     rgba(0,0,0,0.28);
  --accent:      #1565c0;
  --accent-h:    #1976d2;
  --green:       #2e7d32;
  --red:         #c62828;
  --text:        #1a2332;
  --muted:       #4a5568;
  --banner-bg:   rgba(232,237,245,0.97);
  --nav-bg:      #dde3ee;
  --card-shadow: 0 3px 16px rgba(0,0,0,0.18);
}

*, *::before, *::after { box-sizing: border-box; margin: 0; padding: 0; }
html { scroll-behavior: smooth; }

body {
  background: var(--bg);
  color: var(--text);
  font-family: Arial, sans-serif;
  font-size: 14px;
  line-height: 1.6;
  min-height: 100vh;
  padding-top: calc(var(--banner-h) + var(--nav-h));
  transition: background 0.25s, color 0.25s;
}

/* ─── BANNER ─── */
#top-banner {
  position: fixed; top: 0; left: 0; right: 0;
  height: var(--banner-h);
  background: var(--banner-bg);
  border-bottom: 1px solid var(--border2);
  backdrop-filter: blur(8px);
  display: flex; align-items: center; justify-content: space-between;
  padding: 0 28px; z-index: 1000;
  transition: background 0.25s, border-color 0.25s;
}
#top-banner .banner-logo { height: calc(var(--banner-h) - 20px); object-fit: contain; }
#top-banner .banner-title {
  flex: 1; text-align: center;
  font-family: Arial, sans-serif;
  font-size: clamp(1.05rem, 2.2vw, 1.75rem);
  font-weight: 600; letter-spacing: 0.01em;
  color: var(--text); padding: 0 12px; line-height: 1.3;
}
@media (max-width: 640px) {
  :root { --banner-h: 90px; }
  #top-banner .banner-logo { height: 60px; }
  #top-banner { padding: 0 12px; }
  #top-nav    { padding: 0 10px; gap: 2px; }
  #top-nav a  { padding: 5px 9px; font-size: 12px; }
  .theme-toggle { padding: 4px 9px; font-size: 12px; margin-right: 4px; }
  .study-btn  { padding: 4px 9px; font-size: 11px; }
  .container  { padding: 20px 16px; }
}

/* ─── NAV ─── */
#top-nav {
  position: fixed; top: var(--banner-h); left: 0; right: 0;
  height: var(--nav-h); background: var(--nav-bg);
  border-bottom: 1px solid var(--border);
  display: flex; align-items: center; padding: 0 28px; gap: 4px; z-index: 999;
  transition: background 0.25s, border-color 0.25s;
}
#top-nav a {
  color: var(--muted); text-decoration: none; font-size: 13px; font-weight: 500;
  padding: 6px 16px; border-radius: 6px; transition: all 0.18s; letter-spacing: 0.02em;
}
#top-nav a:hover  { color: var(--text); background: var(--surface2); }
#top-nav a.active { color: var(--accent); background: rgba(30,144,255,0.1); }
[data-theme="light"] #top-nav a.active { background: rgba(21,101,192,0.08); }
#top-nav .nav-spacer { flex: 1; }

/* ─── THEME TOGGLE ─── */
.theme-toggle {
  background: var(--surface2); border: 1px solid var(--border2);
  border-radius: 20px; padding: 5px 13px; cursor: pointer;
  font-size: 13px; font-weight: 500; color: var(--text);
  display: flex; align-items: center; gap: 6px;
  transition: all 0.18s; font-family: inherit; margin-right: 8px;
}
.theme-toggle:hover { border-color: var(--accent); color: var(--accent); }

/* ─── STUDY BUTTON ─── */
.study-btn {
  background: rgba(30,144,255,0.1); color: var(--accent);
  border: 1px solid rgba(30,144,255,0.25);
  padding: 5px 14px; border-radius: 6px; cursor: pointer;
  font-size: 12px; font-weight: 500; transition: all 0.18s; font-family: inherit;
}
.study-btn:hover { background: rgba(30,144,255,0.2); }
[data-theme="light"] .study-btn { background: rgba(21,101,192,0.07); border-color: rgba(21,101,192,0.22); }

/* ─── CONTAINER ─── */
.container { max-width: min(1750px, 96vw); margin: 0 auto; padding: 32px 36px; }

/* ─── PAGE TITLE ─── */
.page-title {
  text-align: center; font-family: Arial, sans-serif;
  font-size: 2rem; font-weight: 600; margin-bottom: 28px; color: var(--text);
}

/* ─── SEARCH ─── */
.search-wrap { position: relative; max-width: 640px; margin: 0 auto 36px; }
.search-wrap label {
  display: block; font-size: 12px; color: var(--muted);
  text-transform: uppercase; letter-spacing: 0.08em; margin-bottom: 8px;
}
.search-input {
  width: 100%; background: var(--surface); border: 1px solid var(--border2);
  border-radius: 10px; padding: 12px 44px 12px 16px;
  color: var(--text); font-family: Arial, monospace; font-size: 14px;
  outline: none; transition: border-color 0.2s, box-shadow 0.2s, background 0.25s;
}
.search-input:focus { border-color: var(--accent); box-shadow: 0 0 0 3px rgba(30,144,255,0.12); }
.search-input::placeholder { color: var(--muted); }
.search-clear {
  position: absolute; right: 14px; top: 50%; transform: translateY(-50%);
  background: none; border: none; color: var(--muted); cursor: pointer;
  font-size: 18px; line-height: 1; padding: 4px; display: none;
}
.search-clear:hover { color: var(--text); }

.autocomplete-list {
  position: absolute; top: 100%; left: 0; right: 0;
  background: var(--surface); border: 1px solid var(--border2); border-top: none;
  border-radius: 0 0 10px 10px; max-height: 280px; overflow-y: auto;
  z-index: 500; display: none; box-shadow: var(--card-shadow);
}
.autocomplete-list.open { display: block; }
.autocomplete-item {
  padding: 9px 16px; cursor: pointer;
  display: flex; align-items: baseline; gap: 10px; transition: background 0.12s;
}
.autocomplete-item:hover,
.autocomplete-item.focused { background: var(--surface2); }
.autocomplete-item .ai-name { font-family: Arial, monospace; font-size: 13px; }
.autocomplete-item .ai-tag {
  font-size: 10px; font-weight: 500; padding: 1px 6px; border-radius: 4px;
  background: rgba(30,144,255,0.12); color: var(--accent);
}
.autocomplete-item .ai-tag.gene { background: rgba(46,125,50,0.12); color: var(--green); }
.autocomplete-item .ai-sub { font-size: 11px; color: var(--muted); margin-left: auto; }
.autocomplete-no-results { padding: 12px 16px; color: var(--muted); font-size: 13px; font-style: italic; }

/* ─── WORKFLOW ─── */
#workflow-section { text-align: center; margin: 0 auto; max-width: 1000px; }
#workflow-section h2 {
  font-family: Arial, sans-serif; font-size: 1.4rem; font-weight: 600;
  margin-bottom: 20px; color: var(--muted);
}
#workflow-section img { max-width: 100%; border-radius: 12px; border: 1px solid var(--border); }
[data-theme="light"] #workflow-section img { filter: invert(1) hue-rotate(180deg); }

/* ─── GRIDS ─── */
.two-col { display: grid; grid-template-columns: 1fr 1fr; gap: 24px; }
@media (max-width: 900px) { .two-col { grid-template-columns: 1fr; } }

/* ─── CARD ─── */
.card {
  background: var(--surface); border: 1px solid var(--border);
  border-radius: 12px; padding: 20px; box-shadow: var(--card-shadow);
  overflow: visible;
  transition: background 0.25s, border-color 0.25s;
}
.card-title {
  font-family: Arial, sans-serif; font-size: 1.3rem; font-weight: 600;
  text-align: center; margin-bottom: 14px; padding-bottom: 12px;
  border-bottom: 1px solid var(--border);
  color: var(--text);
}
/* PSOH/PSSH titles intentionally use the same text colour — no special colouring */
.no-data { text-align: center; padding: 40px 20px; color: var(--muted); font-style: italic; font-size: 13px; }
/* Plot containers: JS (buildBoxplot) sets the exact height based on sig-bar count */
.plot-container { width: 100%; overflow: visible; }

/* ─── FC TABLE ─── */
.fc-table-wrap { margin-top: 14px; overflow-x: auto; }
.fc-table { width: 100%; border-collapse: collapse; font-family: Arial, monospace; font-size: 12px; }
.fc-table th {
  background: var(--surface2); color: var(--muted); padding: 8px 12px; text-align: center;
  font-weight: 500; font-size: 11px; text-transform: uppercase; letter-spacing: 0.06em;
  border-bottom: 1px solid var(--border2);
}
.fc-table td { padding: 7px 12px; text-align: center; border-bottom: 1px solid var(--border); color: var(--text); }
.fc-table tr:last-child td { border-bottom: none; }
.fc-table tr:hover td { background: var(--surface2); }
.sig-star { color: var(--text); font-size: 16px; font-weight: 700; }
.sig-ns   { color: var(--muted); font-size: 11px; }
.fc-pos   { color: #ef9a9a; }
.fc-neg   { color: #a5d6a7; }
[data-theme="light"] .fc-pos { color: #b71c1c; }
[data-theme="light"] .fc-neg { color: #1b5e20; }

/* ─── UNIPROT / ALPHAFOLD ─── */
#uniprot-section { margin-top: 32px; }

/* Rich UniProt card */
.uniprot-rich-card {
  background: var(--surface); border: 1px solid var(--border);
  border-radius: 14px; overflow: hidden; box-shadow: var(--card-shadow);
  transition: background 0.25s, border-color 0.25s;
}
.uniprot-rich-header {
  padding: 18px 22px 14px;
  background: linear-gradient(135deg, rgba(30,144,255,0.08) 0%, transparent 60%);
  border-bottom: 1px solid var(--border);
  display: flex; align-items: flex-start; justify-content: space-between; gap: 12px; flex-wrap: wrap;
}
[data-theme="light"] .uniprot-rich-header {
  background: linear-gradient(135deg, rgba(21,101,192,0.06) 0%, transparent 60%);
}
.uniprot-protein-name {
  font-family: Arial, sans-serif; font-size: 1.25rem; font-weight: 600;
  color: var(--text); margin-bottom: 6px; line-height: 1.3;
}
.uniprot-badges { display: flex; flex-wrap: wrap; gap: 6px; margin-bottom: 4px; }
.badge {
  display: inline-flex; align-items: center; gap: 4px;
  font-family: Arial, monospace; font-size: 11px; font-weight: 500;
  padding: 3px 10px; border-radius: 20px; border: 1px solid;
}
.badge-acc   { color: var(--accent); background: rgba(30,144,255,0.1); border-color: rgba(30,144,255,0.22); }
.badge-gene  { color: var(--green);  background: rgba(46,125,50,0.1);  border-color: rgba(46,125,50,0.22); }
.badge-org   { color: var(--muted);  background: var(--surface2);       border-color: var(--border2); }
.uniprot-link {
  display: inline-flex; align-items: center; gap: 6px;
  background: var(--accent); color: white; padding: 7px 14px; border-radius: 7px;
  text-decoration: none; font-size: 12px; font-weight: 500;
  transition: background 0.18s; white-space: nowrap; flex-shrink: 0;
}
.uniprot-link:hover { background: var(--accent-h); }

/* Compartment section */
.uniprot-body { display: grid; grid-template-columns: 1fr 1fr; gap: 0; }
@media (max-width: 700px) { .uniprot-body { grid-template-columns: 1fr; } }

.compartment-panel {
  padding: 18px 22px;
  border-right: 1px solid var(--border);
  display: flex; flex-direction: column; gap: 12px;
}
@media (max-width: 700px) { .compartment-panel { border-right: none; border-bottom: 1px solid var(--border); } }

.compartment-label {
  font-size: 10px; color: var(--muted); text-transform: uppercase; letter-spacing: 0.1em; margin-bottom: 4px;
}
.compartment-pill {
  display: inline-flex; align-items: center; gap: 8px;
  padding: 7px 14px; border-radius: 30px; font-size: 13px; font-weight: 500;
  border: 1px solid; width: fit-content;
}
.subloc-image-wrap,
.sbp-wrap {
  flex: 1; display: flex; align-items: center; justify-content: center;
  min-height: 140px; width: 100%;
}
.subloc-image-wrap img {
  max-width: 100%; max-height: 200px; object-fit: contain;
  border-radius: 8px;
}
/* SwissBioPics web component fills its container */
.sbp-wrap sib-swissbiopics-sl {
  display: block;
  width: 100%;
}
.subloc-fallback {
  width: 100%; min-height: 130px; border-radius: 10px;
  background: var(--surface2); border: 1px dashed var(--border2);
  display: flex; align-items: center; justify-content: center;
  flex-direction: column; gap: 8px; padding: 16px; text-align: center;
  color: var(--muted); font-size: 12px;
}

/* Function/keyword panel */
.uniprot-meta-panel {
  padding: 18px 22px;
  display: flex; flex-direction: column; gap: 14px;
}
.meta-item { display: flex; flex-direction: column; gap: 3px; }
.meta-label { font-size: 10px; color: var(--muted); text-transform: uppercase; letter-spacing: 0.09em; }
.meta-value {
  font-size: 13px; color: var(--text); line-height: 1.5;
  font-family: Arial, monospace;
}
.meta-value.mono { font-family: Arial, monospace; font-size: 12px; }
.function-text {
  font-family: Arial, sans-serif; font-size: 14px;
  color: var(--text); line-height: 1.65;
}

/* AlphaFold card stays the same */
.alphafold-card {
  background: var(--surface); border: 1px solid var(--border);
  border-radius: 12px; overflow: hidden; display: flex; flex-direction: column;
  box-shadow: var(--card-shadow);
}
.alphafold-card .af-header {
  padding: 14px 20px; border-bottom: 1px solid var(--border);
  display: flex; align-items: center; justify-content: space-between;
}
.af-title { font-family: Arial, sans-serif; font-size: 1.1rem; font-weight: 600; }
.alphafold-card iframe { border: none; width: 100%; height: 460px; }

/* ─── MATH CAPTCHA ─── */
.captcha-box {
  background: var(--surface2); border: 1px solid var(--border2);
  border-radius: 10px; padding: 14px 16px;
  display: flex; align-items: center; gap: 16px; flex-wrap: wrap;
}
.captcha-question {
  font-family: Arial, monospace; font-size: 16px; font-weight: 500;
  color: var(--text); white-space: nowrap;
}
.captcha-input {
  width: 80px; background: var(--surface); border: 1px solid var(--border2);
  border-radius: 7px; padding: 8px 10px; color: var(--text);
  font-family: Arial, monospace; font-size: 15px; text-align: center;
  outline: none; transition: border-color 0.18s;
}
.captcha-input:focus { border-color: var(--accent); }
.captcha-hint { font-size: 11px; color: var(--muted); flex-basis: 100%; margin-top: 2px; }

/* ─── PROTEIN HEADER ─── */
.protein-header {
  text-align: center; margin-bottom: 28px; padding: 20px;
  background: var(--surface); border: 1px solid var(--border);
  border-radius: 12px; box-shadow: var(--card-shadow);
  transition: background 0.25s, border-color 0.25s;
}
.protein-header h2 { font-family: Arial, sans-serif; font-size: 1.8rem; font-weight: 600; margin-bottom: 4px; }
.acc-badge {
  display: inline-block; background: rgba(30,144,255,0.1); color: var(--accent);
  font-family: Arial, monospace; font-size: 13px; padding: 3px 12px;
  border-radius: 20px; border: 1px solid rgba(30,144,255,0.22);
}

/* ─── RESULT SECTION ─── */
#result-section { display: none; }
#result-section.visible { display: block; }

/* ─── CORRELATION LAYOUT ─── */
.correlation-layout { display: grid; grid-template-columns: 280px 1fr; gap: 24px; align-items: start; }
@media (max-width: 1050px) { .correlation-layout { grid-template-columns: 1fr; } }
@media (max-width: 640px)  { #scatter-chart { height: 400px; } }

.sidebar-panel {
  background: var(--surface); border: 1px solid var(--border);
  border-radius: 12px; padding: 18px; display: flex; flex-direction: column; gap: 18px;
  box-shadow: var(--card-shadow); transition: background 0.25s, border-color 0.25s;
}
.finder-box { border-radius: 10px; padding: 14px; }
.finder-box.prot-finder { background: rgba(139,0,0,0.12); border: 1px solid rgba(180,0,0,0.2); }
.finder-box.path-finder { background: rgba(15,77,15,0.14); border: 1px solid rgba(0,100,0,0.22); }
[data-theme="light"] .finder-box.prot-finder { background: rgba(183,28,28,0.05); border-color: rgba(183,28,28,0.15); }
[data-theme="light"] .finder-box.path-finder { background: rgba(27,94,32,0.05); border-color: rgba(27,94,32,0.18); }
.finder-box h3 { font-size: 15px; font-weight: 600; margin-bottom: 6px; }
.finder-box p  { font-size: 12px; color: var(--muted); margin-bottom: 10px; }

.finder-textarea {
  width: 100%; background: rgba(0,0,0,0.15); border: 1px solid var(--border2);
  border-radius: 7px; padding: 8px 10px; color: var(--text);
  font-family: Arial, monospace; font-size: 12px;
  resize: vertical; outline: none; transition: border-color 0.18s;
}
[data-theme="light"] .finder-textarea { background: rgba(255,255,255,0.7); }
.finder-textarea:focus { border-color: var(--accent); }

/* ─── BUTTONS ─── */
.btn {
  display: inline-flex; align-items: center; justify-content: center; gap: 6px;
  padding: 7px 16px; border-radius: 7px; font-size: 13px; font-weight: 500;
  cursor: pointer; transition: all 0.18s; border: none; font-family: inherit;
}
.btn-primary { background: var(--accent); color: white; }
.btn-primary:hover { background: var(--accent-h); }
.btn-danger  { background: #8B0000; color: white; border: 1px solid #600000; }
.btn-danger:hover { background: #a40000; }
[data-theme="light"] .btn-danger  { background: #c62828; border-color: #b71c1c; }
.btn-ghost   { background: var(--surface2); color: var(--text); border: 1px solid var(--border2); }
.btn-ghost:hover { border-color: var(--accent); color: var(--accent); }
.btn-row { display: flex; gap: 8px; margin-top: 8px; }
.btn-full { width: 100%; }

/* ─── FORM ELEMENTS ─── */
.form-select, .form-input {
  width: 100%; background: var(--surface2); border: 1px solid var(--border2);
  border-radius: 8px; padding: 9px 12px; color: var(--text);
  font-family: Arial, monospace; font-size: 13px;
  outline: none; transition: border-color 0.18s, background 0.25s; -webkit-appearance: none;
}
.form-select:focus, .form-input:focus { border-color: var(--accent); }
.form-label { display: block; font-size: 11px; color: var(--muted); text-transform: uppercase; letter-spacing: 0.07em; margin-bottom: 6px; }
.form-group { margin-bottom: 14px; }

/* ─── CHARTS ─── */
#scatter-chart { width: 100%; height: 580px; }
.chart-card {
  background: var(--surface); border: 1px solid var(--border);
  border-radius: 12px; padding: 16px; box-shadow: var(--card-shadow);
  transition: background 0.25s, border-color 0.25s;
}
.scatter-legend { display: flex; flex-wrap: wrap; gap: 12px; justify-content: center; margin-top: 10px; font-size: 12px; }
.legend-item { display: flex; align-items: center; gap: 6px; }
.legend-dot { width: 10px; height: 10px; border-radius: 50%; flex-shrink: 0; }

/* ─── CORRELATION DETAIL ─── */
#corr-detail { margin-top: 28px; display: none; }
#corr-detail.visible { display: block; }

/* ─── CONTACT ─── */
.contact-wrap { max-width: 620px; margin: 0 auto; }
.form-textarea {
  width: 100%; background: var(--surface2); border: 1px solid var(--border2);
  border-radius: 8px; padding: 10px 12px; color: var(--text);
  font-family: Arial, sans-serif; font-size: 14px;
  outline: none; resize: vertical; transition: border-color 0.18s;
}
.form-textarea:focus { border-color: var(--accent); }
.form-input-full {
  width: 100%; background: var(--surface2); border: 1px solid var(--border2);
  border-radius: 8px; padding: 10px 12px; color: var(--text);
  font-family: Arial, sans-serif; font-size: 14px;
  outline: none; transition: border-color 0.18s;
}
.form-input-full:focus { border-color: var(--accent); }
.msg-success {
  background: rgba(46,125,50,0.1); border: 1px solid rgba(46,125,50,0.25);
  color: var(--green); padding: 12px 16px; border-radius: 8px; margin-top: 14px; font-size: 14px;
}
.msg-error {
  background: rgba(198,40,40,0.08); border: 1px solid rgba(198,40,40,0.22);
  color: var(--red); padding: 12px 16px; border-radius: 8px; margin-top: 14px; font-size: 14px;
}

/* ─── STUDY POPUP ─── */
#study-overlay {
  position: fixed; inset: 0; background: rgba(0,0,0,0.72);
  z-index: 9999; display: flex; align-items: center; justify-content: center; transition: opacity 0.25s;
}
#study-overlay.hidden { opacity: 0; pointer-events: none; }
#study-box {
  background: var(--surface); border: 1px solid var(--border2);
  border-radius: 14px; padding: 32px 36px; max-width: 640px; width: 90%;
  max-height: 85vh; overflow-y: auto; position: relative;
  box-shadow: 0 24px 80px rgba(0,0,0,0.5);
  animation: popIn 0.3s cubic-bezier(0.34,1.56,0.64,1) both;
  transition: background 0.25s;
}
@keyframes popIn { from { transform:scale(0.88);opacity:0; } to { transform:scale(1);opacity:1; } }
#study-box h2 { font-family: Arial, sans-serif; font-size:1.5rem; font-weight:600; margin-bottom:16px; }
#study-box p  { color:var(--muted); font-size:14px; line-height:1.7; margin-bottom:10px; }
#study-box ul { margin-left:20px; color:var(--muted); font-size:14px; line-height:1.7; }
#study-box ul li { margin-bottom:6px; }
#study-box a { color:var(--accent); }
#study-close {
  position:absolute; top:16px; right:20px; background:none; border:none;
  color:var(--muted); cursor:pointer; font-size:22px; line-height:1; transition:color 0.15s;
}
#study-close:hover { color:var(--text); }
.close-hint { margin-top:18px; font-size:12px; color:var(--muted); text-align:center; font-style:italic; }

/* ─── FOOTER ─── */
footer { margin-top:60px; border-top:1px solid var(--border); padding:20px 28px; text-align:center; font-size:12px; color:var(--muted); }
footer a { color:var(--accent); text-decoration:none; }

/* ─── MISC ─── */
.spinner-wrap { text-align:center; padding:40px; color:var(--muted); font-size:13px; }
.spinner { display:inline-block; width:28px; height:28px; border:2px solid var(--border2); border-top-color:var(--accent); border-radius:50%; animation:spin 0.7s linear infinite; margin-bottom:10px; }
@keyframes spin { to { transform:rotate(360deg); } }
.loading-text { color:var(--muted); font-size:13px; font-style:italic; text-align:center; padding:20px; }
::-webkit-scrollbar { width:6px; height:6px; }
::-webkit-scrollbar-track { background:var(--bg); }
::-webkit-scrollbar-thumb { background:var(--surface2); border-radius:3px; }